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Publication - Professor Stafford Lightman

    The crucial role of pulsatile activity of the HPA axis for continuous dynamic equilibration

    Citation

    Lightman, S & Conway-Campbell, B, 2010, ‘The crucial role of pulsatile activity of the HPA axis for continuous dynamic equilibration’. Nature Reviews Neuroscience, vol 11., pp. 710 - 718

    Abstract

    The classical concept of hypothalamus-pituitary-adrenal (HPA) homeostasis comprises a feedback system within which circulating levels of glucocorticoid hormones maintain the brain and body in an optimal steady state. However, studies involving new techniques for investigating the real-time dynamics of both glucocorticoid hormones and glucocorticoid receptor function paint a different picture - namely, of continuous dynamic equilibration throughout this neuroendocrine system. This dynamic state is dictated by feedforward and feedback regulatory loops and by stochastic interactions at the level of DNA binding. We propose that this continuous oscillatory activity is crucial for optimal responsiveness of glucocorticoid-sensitive neural processes.

    Full details in the University publications repository