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Publication - Professor Pete Cullen

    Retromer Controls Planar Polarity Protein Levels and Asymmetric Localization at Intercellular Junctions

    Citation

    Strutt, H, Langton, PF, Pearson, N, McMillan, KJ, Strutt, D & Cullen, PJ, 2019, ‘Retromer Controls Planar Polarity Protein Levels and Asymmetric Localization at Intercellular Junctions’. Current Biology, vol 29., pp. 484-491.e6

    Abstract

    Planar cell polarity—the organization of cells within a two-dimensional plane—is an important feature in tissue organization. Strutt et al. show that, in the Drosophila wing, endosomal recycling through retromer and its cargo adaptor Snx27 mediates the cell-surface localization of two key planar polarity proteins, Flamingo and Strabismus.

    Full details in the University publications repository