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Publication - Professor Kei Cho

    Tau phosphorylation at serine 396 residue is required for hippocampal LTD

    Citation

    Regan, P, Piers, T, Yi, JH, Kim, DH, Huh, S, Park, SJ, Ryu, JH, Whitcomb, DJ & Cho, K, 2015, ‘Tau phosphorylation at serine 396 residue is required for hippocampal LTD’. Journal of Neuroscience, vol 35., pp. 4804-4812

    Abstract

    Tau is required for the induction of long-term depression (LTD) of synaptic transmission in the hippocampus. Here we probe the role of tau in LTD, finding that an AMPA receptor internalization mechanism is impaired in tau KO mice, and that LTD causes specific phosphorylation at the serine 396 and 404 residues of tau. Surprisingly, we find that phosphorylation at serine 396, specifically, is critical for LTD but has no role in LTP. Finally, we show that tau KO mice exhibit deficits in spatial reversal learning. These findings underscore the physiological role for tau at the synapse and identify a behavioral correlate of its role in LTD.

    Full details in the University publications repository