Browse/search for people

Publication - Professor Kei Cho

    Aβ(1-42) inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β

    Citation

    Jo, J, Whitcomb, DJ, Olsen, KM, Kerrigan, TL, Lo, S-C, Bru-Mercier, G, Dickinson, B, Scullion, S, Sheng, M, Collingridge, G & Cho, K, 2011, ‘Aβ(1-42) inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β’. Nature Neuroscience, vol 14., pp. 545 - 547

    Abstract

    Amyloid-β(1-42) (Aβ) is thought to be a major mediator of the cognitive deficits in Alzheimer's disease. The ability of Aβ to inhibit hippocampal long-term potentiation provides a cellular correlate of this action, but the underlying molecular mechanism is only partially understood. We found that a signaling pathway involving caspase-3, Akt1 and glycogen synthase kinase-3β is an important mediator of this effect in rats and mice.

    Full details in the University publications repository