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Professor Kei Cho

Professor Kei Cho

Professor Kei Cho
Ph.D

Honorary Professor of Bristol Medical School

Area of research

Synaptic Plasticity and Alzheimer's Disease

Dorothy Hodgkin Building,
Whitson Street, Bristol BS1 3NY
(See a map)

+44 (0) 117 331 3048

Summary

Research in Cho group focuses on a wide range of projects from molecular mechanisms of synaptic plasticity in the brain to pathological aspects of the central nervous system (CNS) including Alzheimer's disease. This is achieved through electrophysiological recordings, calcium imaging, molecular biology, cell culture, gene transfection, immunocytochemical techniques and MRI-brain imaging.


The plastic nature of synapses means that long-term potentiation (LTP, a prolonged increase in synaptic transmission) and long-term depression (LTD, a long-lasting depression of synaptic transmission) can be induced.

Using brain slice electrophysiology and calcium imaging techniques, our findings from the hippocampus and perirhinal cortex have suggested a new form of LTD in which G-protein coupled metabotropic glutamate receptors (mGluRs) have an important role. These findings have led to a greater understanding of mechanisms that regulate mGluRs and the ways in which mGluRs interact with other receptors. Our group is also investigating the molecular roles of postsynaptic calcium sensors and caspase-cascades in hippocampal and perirhinal LTP.

Activities / Findings

  • Roles of Beta-Amyloid in synaptic dysfunction.
  • Tau and synapse weakening pathways.
  • Roles of postsynaptic calcium sensors and caspase-cascades in long-term synaptic plasticity.
  • Stress-related hormones in excitatory synaptic transmission.
  • Aging and stress-related decline of recognition memory.

Keywords

  • beta-amyloid
  • excitatory synapse
  • long-term synaptic plasticity
  • calcium-sensor
  • brain atrophy
  • stress
  • jet-lag
  • stem-cell

Skills

  • Alzheimer's disease
  • Amyloid-beta toxicity
  • Stress
  • Neurodegeneration

Processes and functions

  • Synaptic Plasticity
  • Recogntion Memory
  • Stem-cell differentiation

Methodologies

  • Whole-cell patch recording (multiple electrode patch / single electrode patch)
  • Organotypic brain slice culture
  • Primary cell culture
  • Calcium imaging (slice and primary cultured neuron)
  • Gene transfection
  • Western-blot
  • GST-pull down
  • Co-immunopreciepetation
  • Stem-cell differentiation
  • neuronal transplantation
  • MRI brain volumetric analysis
  • Human cognition

Selected publications

Read more >

Recent publications

View complete publications list in the University of Bristol publications system

Networks & contacts

  • Prof Eunjoon Kim (IBS-KAIST - Korea)
  • Prof Graham Collingridge (MRC Centre - Bristol)
  • Prof Stafford Lightman (Henry Wellcome LINE - Bristol)
  • Prof Morgan Sheng (Genentech - USA)
  • Prof Peter St George-Hyslop (Cambridge)
  • Prof. David Klenerman (Cambridge)
  • Dr. Lisa Saksida (Cambridge)

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