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Publication - Dr David Benito-Alifonso

    Quantum dot-based probes for labeling and imaging of cells that express matrix metalloproteinases (MT-MMPs)

    Citation

    Benito-Alifonso, D, Richichi, B, Baldoneschi, V, Berry, M, Fragai, M, Salerno, G, Galan, C & Nativi, C, 2018, ‘Quantum dot-based probes for labeling and imaging of cells that express matrix metalloproteinases (MT-MMPs)’. ACS Omega.

    Abstract

    The practical synthesis of novel multivalent fluorescent Quantum Dot (QD)-based probes to target cellular matrix metalloproteinases (MT-MMPs) is reported. We show that these probes, which are decorated with a nanomolar water-soluble MMP inhibitor, can be used to label preferentially the surface of cancer cells that are known to express MMPs while no binding was observed on cells that do not.

    Full details in the University publications repository