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Dr James Hodge

Dr James Hodge

Dr James Hodge
B.Sc.(Sheff.), Ph.D.(Cantab.)

Senior Lecturer

Area of research

Changes in excitability of neural circuits underlying behaviour and disease

Office F33
Biomedical Sciences Building,
University Walk, Bristol BS8 1TD
(See a map)

Tel. +44 (0) 117 331 1416

Research summary

Research interests
We are interested in the molecular mechanisms and neural circuit changes that underlie behavior. We are taking advantage of the fantastic genetic toolbox available in Drosophila to tackle this problem.  
 

We are studying how dynamic changes in calcium through CaMKII bring about changes in synaptic plasticity underlying memory. Key to this process is CaMKII’s ability to autophosphorylate a mechanism dubbed “the molecular memory switch” which is regulated by a synaptic scaffolding molecule called CASK. Dr Bilal Malik and John Gillespie showed that CASK regulates dynamic changes in calcium and CaMKII autophosphorylation both in negatively and positively ...

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Selected publications

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View complete publications list in the University of Bristol publications system

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