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Publication - Professor Matthew Hickman

    Global, regional, and country-level estimates of hepatitis C infection among people who have recently injected drugs

    Citation

    Grebely, J, Larney, S, Peacock, A, Colledge, S, Leung, J, Hickman, M, Vickerman, P, Blach, S, Cunningham, E, Dumchev, K, Lynskey, M, Stone, J, Trickey, A, Razavi, H, Mattick, RP, Farrell, M, Dore, G & Degenhardt, L, 2019, ‘Global, regional, and country-level estimates of hepatitis C infection among people who have recently injected drugs’. Addiction, vol 114., pp. 150-166

    Abstract

    Background and Aims
    People who have recently injected drugs are a priority population in efforts to achieve hepatitis C virus (HCV) elimination. This study estimated the prevalence and number of people with recent injecting drug use living with HCV, and the proportion of people with recent injecting drug use among all people living with HCV infection at global, regional and country‐levels.

    Methods
    Data from a global systematic review of injecting drug use and HCV antibody prevalence among people with recent (previous year) injecting drug use were used to estimate the prevalence and number of people with recent injecting drug use living with HCV. These data were combined with a systematic review of global HCV prevalence to estimate the proportion of people with recent injecting drug use among all people living with HCV.

    Results
    There are an estimated 6.1 million [95% uncertainty interval (UI) = 3.4–9.2] people with recent injecting drug use aged 15–64 years living with HCV globally (39.2% viraemic prevalence; UI = 31.6–47.0), with the greatest numbers in East and Southeast Asia (1.5 million, UI = 1.0–2.1), eastern Europe (1.5 million, UI = 0.7–2.4) and North America (1.0 million, UI = 0.4–1.7). People with recent injecting drug use comprise an estimated 8.5% (UI = 4.6–13.1) of all HCV infections globally, with the greatest proportions in North America (30.5%, UI = 11.7–56.7), Latin America (22.0%, UI = 15.3–30.4) and eastern Europe (17.9%, UI = 8.2–30.9).

    Conclusions
    Although, globally, 39.2% of people with recent injecting drug use are living with hepatitis C virus (HCV) and 8.5% of all HCV infections occur globally among people with recent injecting drug use, there is wide variation among countries and regions.

    Full details in the University publications repository