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Publication - Dr Borko Amulic

    Cell-Cycle Proteins Control Production of Neutrophil Extracellular Traps


    Amulic, B, Knackstedt, SL, Abu Abed, U, Deigendesch, N, Harbort, CJ, Caffrey, BE, Brinkmann, V, Heppner, FL, Hinds, PW & Zychlinsky, A, 2017, ‘Cell-Cycle Proteins Control Production of Neutrophil Extracellular Traps’. Developmental Cell, vol 43., pp. 449-462.e5


    Neutrophils are essential for immune defense and can respond to infection by releasing chromatin in the form of neutrophil extracellular traps (NETs). Here we show that NETs are induced by mitogens and accompanied by induction of cell-cycle markers, including phosphorylation of the retinoblastoma protein and lamins, nuclear envelope breakdown, and duplication of centrosomes. We identify cyclin-dependent kinases 4 and 6 (CDK4/6) as essential regulators of NETs and show that the response is inhibited by the cell-cycle inhibitor p21Cip. CDK6, in neutrophils, is required for clearance of the fungal pathogen Candida albicans. Our data describe a function for CDK4/6 in immunity.

    Full details in the University publications repository