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Professor Mark Szczelkun

Expertise

Mechanism, control and diversity of molecular motors on DNA. Many genetic processes require the action of large protein machines that act on DNA as a function of ATP hydrolysis. In this way these complexes act as ?molecular motors? ? they convert chemical energy as ATP into mechanical events. Our lab is interested in how ATP hydrolysis is used to communicate between distant sites on DNA, sites which may be many thousands of base pairs distant. We are currently concentrating on two processes: (1) The cleavage of DNA by the ATP-dependent restriction enzymes; and (2) The repair of DNA damage by the mismatch repair system.

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Key words

  • molecular motors
  • DNA
  • genetic processes
  • protein
  • ATP hydrolysis
  • cleavage of DNA
  • restriction enzymes