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Dr Deborah Shoemark

Dr Deborah Shoemark

Dr Deborah Shoemark
B.Sc., Ph.D.(Bristol)

Senior Research Associate (Biomolecular Modelling)

Office C62
Biomedical Sciences Building,
University Walk, Clifton BS8 1TD
(See a map)

Tel. +44 (0) 117 331 2146

Research summary

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Biography

Following my degree in medical biochemistry I gained a PhD in enzymology, both at Bristol University, with Professors John Holbrook and Anthony Clarke. I spent my first post-doc combining enzymology with structural biology and mutagenesis to further explore enzyme structure and function. I then moved into drug discovery programmes as a molecular modeller involving Trks A and B and the neurotrophins. This work was targeting pain management (in the periphery) and Alzheimer's disease (centrally). Following that I worked with the MRC Prion Unit and identified compounds capable of stabilizing the human prion protein with low micromolar affinity towards a treatment ...

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Recent publications

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View complete publications list in the University of Bristol publications system

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