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Professor Christiane Berger-Schaffitzel

Professor Christiane Berger-Schaffitzel

Professor Christiane Berger-Schaffitzel
MSc(Hannover), PhD(Zurich), Habiliation (E.T.H.Zurich)

Professor of Biochemistry

Area of research

Translation, Protein and mRNA Quality Control

Office B102
Biomedical Sciences Building,
University Walk, Clifton BS8 1TD
(See a map)

Tel. +44 (0) 117 39 41869

Research summary

Current work in the lab ranges from eukaryotic translation initiation, via regulation of translation termination to co-translational translocation of membrane proteins via the bacterial holo-translocon. We are particularly interested in how cells recognize problems during protein synthesis and target the defective proteins and their encoding mRNAs to degradation. These processes are vital to all organisms, and even minor problems in mRNA or protein quality control mechanisms give rise to diseases. Our research is funded by the BBSRC and MRC and recently via a Wellcome Trust Investigator Award.

In all our projects, we rely on biochemical methods, using in vitro translation ...

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mRNA Quality Control Mechanisms

Nonsense-mediated mRNA decay (NMD) is an essential mechanism controlling translation in the eukaryotic cell. NMD ascertains accurate expression of the genetic information by quality controlling messenger RNA (mRNA). During translation, NMD factors recognize and target to degradation aberrant mRNAs that have a premature stop codon (PTC) and that would otherwise lead to the production of truncated proteins which could be harmful for the cell. Discrimination of a PTC from a correct termination codon depends on splicing and translation, and it is the first and foremost step in human NMD. However, the underlying molecular mechanisms remain ...

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Selected publications

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View complete publications list in the University of Bristol publications system

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