Dr Deborah Shoemark

Research summary

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Biography

Following my degree in medical biochemistry I gained a PhD in enzymology, both at Bristol University, with Professors John Holbrook and Anthony Clarke. I spent my first post-doc combining enzymology with structural biology and mutagenesis to further explore enzyme structure and function. I then moved into drug discovery programmes as a molecular modeller involving Trks A and B and the neurotrophins. This work was targeting pain management (in the periphery) and Alzheimer's disease (centrally). Following that I worked with the MRC Prion Unit and identified compounds capable of stabilizing the human prion protein with low micromolar affinity towards a treatment ...

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Recent publications

• Oliveira, ASF, Shoemark, DK, Campello, HR, Wonnacott, S, Gallagher, T, Sessions, RB & Mulholland, AJ, 2019, ‘Identification of the Initial Steps in Signal Transduction in the α4β2 Nicotinic Receptor: Insights from Equilibrium and Nonequilibrium Simulations’. Structure, vol 27., pp. 1171-1183.e3
• Shoemark, DK, Ibarra, AA, Ross, JF, Beesley, JL, Bray, HE, Mosayebi, M, Linden, N, Liverpool, TB, McIntosh-Smith, SN, Woolfson, DN & Sessions, RB, 2019, ‘The dynamical interplay between a megadalton peptide nanocage and solutes probed by microsecond atomistic MD; Implications for design’. Physical Chemistry Chemical Physics, vol 21., pp. 137-147

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View complete publications list in the University of Bristol publications system