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Publication - Dr Katherine Williams

    Characterisation of the biosynthetic pathway to agnestins A and B reveals the reductive route to chrysophanol in fungi

    Citation

    Szwalbe, AJ, Williams, K, Song, Z, De Mattos-Shipley, K, Vincent, JL, Bailey, AM, Willis, CL, Cox, RJ & Simpson, TJ, 2019, ‘Characterisation of the biosynthetic pathway to agnestins A and B reveals the reductive route to chrysophanol in fungi’. Chemical Science, vol 10., pp. 233-238

    Abstract

    Two new dihydroxy-xanthone metabolites, agnestins A and B, were isolated from Paecilomyces variotii along with a number of related benzophenones and xanthones including monodictyphenone. The structures were elucidated by NMR analyses and X-ray crystallography. The agnestin (agn) biosynthetic gene cluster was identified and targeted gene disruptions of the PKS, Baeyer-Villiger monooxygenase, and other oxido-reductase genes revealed new details of fungal xanthone biosynthesis. In particular, identification of a reductase responsible for in vivo anthraquinone to anthrol conversion confirms a previously postulated essential step in aromatic deoxygenation of anthraquinones, e.g. emodin to chrysophanol.

    Full details in the University publications repository