Dr Andrea Brancaccio

Research summary

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Biography

Andrea Brancaccio obtained his PhD degree in Biochemistry at the Sapienza University in Rome in 1994 characterizing recombinant myoglobins. He then moved to the Biozentrum of the University of Basel with a post-doctoral position in the laboratory of Prof. Jürgen Engel where his research interest focused on the extracellular matrix and in particular on dystroglycan. During this period, he collected the very first structural data on alpha-dystroglycan using electron microscopy on the native molecule as well as on some recombinant fragments, thus discovering an N-terminal autonomous module whose structure he subsequently contributed to solve by X-ray crystallography. During his post-doc ...

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Selected publications

• Dempsey, C, Bigotti, MG, Adams, J & Brancaccio, A, 2019, ‘Analysis of α-dystroglycan/LG domain binding modes: investigating protein motifs that regulate the affinity of isolated LG domains’. Frontiers in Molecular Biosciences, vol 6.
• Brancaccio, A, 2019, ‘A molecular overview of the primary dystroglycanopathies’. Journal of Cellular and Molecular Medicine, vol 23., pp. 3058-3062

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Recent publications

• Signorino, G, Covaceuszach, S, Bozzi, M, Hubner, W, Mönkemöller, V, Konarev, PV, Cassetta, A, Brancaccio, A & Sciandra, F, 2018, ‘A dystroglycan mutation (p.Cys667Phe) associated to muscle-eye-brain disease with multicystic leucodystrophy results in ER-retention of the mutant protein’. Human Mutation, vol 39., pp. 266-280
• Gioia, M, Fasciglione, GF, Sbardella, D, Sciandra, F, Casella, M, Camerini, S, Crescenzi, M, Gori, A, Tarantino, U, Cozza, P, Brancaccio, A, Coletta, M & Bozzi, M, 2018, ‘The enzymatic processing of α-dystroglycan by MMP-2 is controlled by two anchoring sites distinct from the active site’. PLoS ONE, vol 13., pp. e0192651

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View complete publications list in the University of Bristol publications system