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Professor Jan Frayne

Professor Jan Frayne

Professor Jan Frayne
B.Sc.(Nott.), Ph.D.(Bristol)

Professor in Molecular Cell Biology

Area of research

The molecular analysis of erythroid cells generated in vitro from different stem cell sources

Office DW18
Biomedical Sciences Building,
University Walk, Clifton BS8 1TD
(See a map)

Tel. +44 (0) 117 331 2127

Research summary

The generation of RBCs in vitro for transfusion therapy is a major goal of health services globally. My research is focussed on the development of in vitro systems to generate human erythroid cells from different stem cell sources, including adult, cord and iPSCs, and the molecular analysis of these cells. We utilise innovative proteomic approaches to qualitatively and quantitatively compare the differential proteome of erythroblasts from the different stem cells, along with genetic engineering to alter the behaviour and phenotype. I am also interested in the regulation of erythropoiesis by transcription factors and our studies have revealed both novel transcription ...

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Jan Frayne obtained her first degree from Nottingham University and PhD from Bristol University before commencing research in developmental biology, specifically molecular aspects of spermatogenesis and sperm function. She moved to the Department of Biochemistry at the University of Bristol on a post-doctoral position within this area, obtaining a lectureship here in 2000. Although still maintaining an active interest in this area, in 2004 Jans interests diversified to study of erythropoiesis. 

Blood shortage is an important healthcare problem globally, with much interest in generating red blood cells in vitro from stem cells as an alternative to donor blood, with ...

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Recent publications

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View complete publications list in the University of Bristol publications system

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