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Dr Helen Weavers

Dr Helen Weavers

Dr Helen Weavers

Research Fellow

Area of research

Understanding the cell biology of tissue resilience during development, inflammation and wound repair

Office C21a
Biomedical Sciences Building,
University Walk, Clifton BS8 1TD
(See a map)

Tel. +44 (0) 117 331 1657

Research summary

Our tissues are frequently exposed to a wide-range of endogenous and exogenous insults that could threaten the integrity of their genome, proteome and metabolome. This occurs when tissues are injured, as inflammatory cells generate toxic products, and also in otherwise healthy tissues as similar products are generated as a normal byproduct of cellular metabolism and physiology. How do our tissues withstand these insults? In our lab, we explore the diverse, powerful defense strategies used by developing and repairing tissues to make them resilient to this damage.

We use an exciting interdisciplinary approach that combines in vivo imaging and genetics in ...

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I began my research career as a Research Assistant and later Wellcome Trust-funded PhD student with Professor Helen Skaer (University of Cambridge) studying renal development using Drosophila as a powerful, genetically tractable in vivo model. We found that fruitflies possess podocyte-like cells called ‘nephrocytes’, which share striking molecular, structural and functional parallels with their mammalian counterparts (Weavers et al., 2009 Nature). I also found that inter-tissue crosstalk was essential for kidneys to develop with stereotypical 3-dimensional looped architecture (Weavers & Skaer, 2013 Dev Cell).

Building on my interest in tissue morphogenesis, I undertook a postdoc with Professors Paul Martin and ...

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Recent publications

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View complete publications list in the University of Bristol publications system

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