Professor Catherine Nobes

Research summary

Our work is of relevance to tumour cell motility and invasion. We are interested in understanding the molecular pathways that direct cancer cells away from the primary tumour and how the tumour microenvironment contributes to cancer cell migration and metastasis.

We work on a phenomenon known as contact inhibition of locomotion; collisions between migrating cells lead to collapse of actin-driven cell protrusions and a change in the direction of migration. Many cancer cells fail to show contact inhibition of locomotion when confronted to normal cells and this switch to attractive migratory behaviour has been suggested to underlie invasive metastasis. We ...

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Recent publications

• Hampton-O'Neil, L, Severn, C, Gurung, S, Cross, S, Nobes, C & Toye, A, 2019, ‘Ephrin/Eph receptor interaction facilitates macrophage recognition of differentiating human erythroblasts’. Haematologica, vol 104.
• Taylor, H, Campbell, JD & Nobes, CD, 2017, ‘Ephs and ephrins’. Current Biology, vol 27., pp. R90-R95

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View complete publications list in the University of Bristol publications system