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Professor Catherine Nobes

Professor Catherine Nobes

Professor Catherine Nobes
B.Sc., Ph.D.(Lond.)

Professor of Cell Biology
Head of School

Area of research

Regulation of cell migration and cancer cell invasion by Eph receptors and ephrins

Office D30.g
Biomedical Sciences Building,
University Walk, Clifton BS8 1TD
(See a map)

Tel. +44 (0) 117 331 2164

Research summary

Our work is of relevance to tumour cell motility and invasion. We are interested in understanding the molecular pathways that direct cancer cells away from the primary tumour and how the tumour microenvironment contributes to cancer cell migration and metastasis.

We work on a phenomenon known as contact inhibition of locomotion; collisions between migrating cells lead to collapse of actin-driven cell protrusions and a change in the direction of migration. Many cancer cells fail to show contact inhibition of locomotion when confronted to normal cells and this switch to attractive migratory behaviour has been suggested to underlie invasive metastasis. We ...

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Recent publications

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View complete publications list in the University of Bristol publications system

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