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Professor Catherine Nobes
Professor Catherine Nobes
B.Sc., Ph.D.(Lond.)
Professor of Cell Biology
Head of School
Area of research
Regulation of cell migration and cancer cell invasion by Eph receptors and ephrins
Summary
Our work is of relevance to tumour cell motility and invasion. We are interested in understanding the molecular pathways that direct cancer cells away from the primary tumour and how the tumour microenvironment contributes to cancer cell migration and metastasis.
We work on a phenomenon known as contact inhibition of locomotion; collisions between migrating cells lead to collapse of actin-driven cell protrusions and a change in the direction of migration. Many cancer cells fail to show contact inhibition of locomotion when confronted to normal cells and this switch to attractive migratory behaviour has been suggested to underlie invasive metastasis. We have shown that EphB receptors are upregulated in metastatic prostate cancer cells and are functionally required for attractive migration after contact with stromal fibroblasts and endothelial cells.
My group continues to focus on how Eph-ephrin signalling regulates cell migration and cell-cell interactions in the context of cancer and wound healing.
Teaching
Molecular Cell Biology
Cell Biology of Development and Disease
Research and Communication Skills
Extended Research Project
Advanced Cell Biology
Advanced Options in Biochemistry
The Dynamic Cell
The Dynamic Cell (MSc)
Big Ideas in Science
Medical students - Student Choice Project 1
Student Choice Placement – Molecular and Cellular Basis of Disease
Recent publications
- Hampton-O'Neil, L, Severn, C, Gurung, S, Cross, S, Nobes, C & Toye, A, 2019, Ephrin/Eph receptor interaction facilitates macrophage recognition of differentiating human erythroblasts. Haematologica, vol 104.
- Taylor, H, Campbell, JD & Nobes, CD, 2017, Ephs and ephrins. Current Biology, vol 27., pp. R90-R95
- Nunan, R, Campbell, J, Mori, R, Pitulescu, ME, Jiang, WG, Harding, KG, Adams, RH, Nobes, CD & Martin, PB, 2015, Ephrin-Bs Drive Junctional Downregulation and Actin Stress Fiber Disassembly to Enable Wound Re-epithelialization. Cell Reports, vol 13., pp. 1380?1395
- Batson, J, Maccarthy-Morrogh, L, Archer, A, Tanton, H & Nobes, CD, 2014, EphA receptors regulate prostate cancer cell dissemination through Vav2-RhoA mediated cell-cell repulsion. Biology Open, vol 3., pp. 453-62
- Batson, J, Astin, JW & Nobes, CD, 2013, Regulation of contact inhibition of locomotion by Eph-ephrin signalling. Journal of Microscopy, vol 251., pp. 232-41
- Kadir, S, Astin, J, tahtamouni, L, Martin, P & Nobes, C, 2011, Microtubule remodelling is required for the front-rear polarity switch during contact inhibition of locomotion. Journal of Cell Science, vol 124., pp. 2642 - 2653
- Wang, Y, Nakayama, M, Pitulescu, M, Schmidt, T, Bochenek, M, Sakakibara, A, Adams, S, Davy, A, Deutsch, U, Lüthi, U, Barberis, A, Benjamin, L, Mäkinen, T, Nobes, C & Adams, R, 2010, Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis. Nature, vol 465 ., pp. 483 - 489
- Bochenek, M, Dickinson, S, Astin, J, Adams, R & Nobes, C, 2010, Ephrin-B2 regulates endothelial cell morphology and motility independently of Eph-receptor binding. Journal of Cell Science, vol 123 ., pp. 1235 - 1246
- Astin, J, Batson, J, Kadir, S, Charlet, J, Persad, R, Gillatt, D, Oxley, J & Nobes, C, 2010, Competition amongst Eph receptors regulates contact inhibitions of locomotion and invasiveness in prostate cancer cells. Nature Cell Biology, vol 12 (12)., pp. 1194 - 1204
- Groeger, G & Nobes, C, 2007, Co-operative Cdc42 and Rho signalling mediates ephrinB-triggered endothelial cell retraction. Biochemical Journal, vol 404 (1)., pp. 23 - 29
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