Professor Kei Cho

Research summary

Research in Cho group focuses on a wide range of projects from molecular mechanisms of synaptic plasticity in the brain to pathological aspects of the central nervous system (CNS) including Alzheimer's disease. This is achieved through electrophysiological recordings, calcium imaging, molecular biology, cell culture, gene transfection, immunocytochemical techniques and MRI-brain imaging.

The plastic nature of synapses means that long-term potentiation (LTP, a prolonged increase in synaptic transmission) and long-term depression (LTD, a long-lasting depression of synaptic transmission) can be induced.

Using brain slice electrophysiology and calcium imaging techniques, our findings from the hippocampus and perirhinal cortex have suggested a ...

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Links

•   UK-Korea Neuroscience Consortium

Selected publications

• Regan, P, Piers, T, Yi, JH, Kim, DH, Huh, S, Park, SJ, Ryu, JH, Whitcomb, DJ & Cho, K, 2015, ‘Tau phosphorylation at serine 396 residue is required for hippocampal LTD’. Journal of Neuroscience, vol 35., pp. 4804-4812
• Jo, J, Whitcomb, DJ, Olsen, KM, Kerrigan, TL, Lo, S-C, Bru-Mercier, G, Dickinson, B, Scullion, S, Sheng, M, Collingridge, G & Cho, K, 2011, ‘Aβ(1-42) inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β’. Nature Neuroscience, vol 14., pp. 545 - 547

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Recent publications

• Park, D, Lee, U, Cho, E, Zhao, H, Kim, JA, Lee, BJ, Regan, P, Ho, WK, Cho, K & Chang, S, 2018, ‘Impairment of Release Site Clearance within the Active Zone by Reduced SCAMP5 Expression Causes Short-Term Depression of Synaptic Release’. Cell Reports, vol 22., pp. 3339-3350
• Yi, JH, Kim, DH, Piers, TM, Kim, SC, Whitcomb, DJ, Regan, P & Cho, K, 2018, ‘Postsynaptic p47phox regulates long-term depression in the hippocampus’. Cell Discovery, vol 4.

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View complete publications list in the University of Bristol publications system