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Publication - Dr Margaritis Voliotis

    Mathematical modeling of gonadotropin-releasing hormone signaling


    Pratap, A, Garner, KL, Voliotis, M, Tsaneva-Atanasova, K & McArdle, CA, 2017, ‘Mathematical modeling of gonadotropin-releasing hormone signaling’. Molecular and Cellular Endocrinology, vol 449., pp. 42-55


    Gonadotropin-releasing hormone (GnRH) acts via G-protein coupled
    receptors on pituitary gonadotropes to control of reproduction. These
    are Gq-coupled receptors that mediate acute effects of GnRH
    on the exocytotic secretion of luteinizing hormone (LH) and
    follicle-stimulating hormone (FSH), as well as the chronic regulation of
    their synthesis. GnRH is secreted in short pulses and GnRH effects on
    its target cells are dependent upon the dynamics of these pulses. Here
    we overview GnRH receptors and their signaling network, placing emphasis
    on pulsatile signaling, and how mechanistic mathematical models and an
    information theoretic approach have helped further this field.

    Full details in the University publications repository