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Professor Mumtaz Virji

Expertise

Past Research ? Mechanisms of Neisseria gonorrhoeae pathogenesis: studies on the roles of surface components in virulence. ? Molecular mechanisms of interactions of Neisseria meningitidis and Haemophilus influenzae with human endothelial, epithelial and phagocytic cells. ? Influence of post-translational modifications of meningococcal pili on their functions Current Research ? Molecular basis of common receptor targeting by Neisseria meningitidis and Haemophilus influenzae and other mucosal pathogens and colonisers ? Mechanisms of mucosal colonisation by commensal neisserial species. ? Development of in vitro models that mimic post inflammatory state of host target cells to examine the influence of cellular receptor profiles on increased susceptibility to meningococcal infection. ? Molecular analysis of the interactions of Neisseria meningitidis and Haemophilus influenzae with polarised human epithelial cells ? Mechanisms of Neisseria meningitidis targeting of serum factors and intracellular cytoskeletal protein alpha actinin ? Studies on Structure, function and mechanics of the Moraxella catarrhalis adhesin UspA1

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Key words

  • Mechanisms of Neisseria gonorrhoeae pathogenesis
  • surface components in virulence
  • mucosal pathogens and colonisers
  • mucosal colonisation by commensal neisserial species
  • meningococcal infection
  • Moraxella catarrhalis adhesin UspA1