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Publication - Dr Darryl Hill

    Haemophilus influenzae meningitis


    Hill, DJ & Christodoulides, M, 2013, ‘Haemophilus influenzae meningitis’. in: Meningitis: cellular and molecular basis. CABI Publishing, pp. 91-103


    This chapter reviews the pathogenesis of Haemophilus influenzae type b (Hib) meningitis, a multistep process that begins with: (i) colonization of the nasopharynx; (ii) subsequent invasion into the blood, which leads to haematogenous dissemination; (iii) bacterial penetration of the blood-cerebrospinal fluid barrier/blood-brain barrier and entry into the subarachnoid space; which leads to (iv) a compartmentalized host inflammatory response. A newborn rat model for Hib meningitis is proposed, which is based on current knowledge of bacterial virulence factors and host cell receptor recognition of these ligands.

    Full details in the University publications repository