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Professor Paul Race

Professor Paul Race

Professor Paul Race
BSc(Leeds), PhD(Birm.)

Professor of Biological Chemistry

Office Room C.101b
Biomedical Sciences Building,
University Walk, Clifton BS8 1TD
(See a map)

+44 (0) 117 33 11835

Summary

Teaching

Biophysics and Molecular Life Sciences i

Biological Chemistry

Science and Society

Synthetic Biology

Science in Society

Biomedical Research, Employability and Enterprise Skills

The Dynamic Proteome

Advanced Options in Biochemistry

Expertise

I am interested in natural products synthesised by the polyketide and related non-ribosomal peptide pathways. My research group employs a range of structural (X-ray crystallography, cryo-electron microscopy, NMR and solution scattering) and functional (enzyme kinetics, spectroscopy, etc.) methods to deconvolute, at the molecular level, the catalytic mechanisms of the individual component enzymes from selected synthetic pathways. These investigations form the basis of protein engineering approaches, where we seek to manipulate pathway enzymes to yield novel derivative products with improved therapeutic activities. Other areas of major interest include hybrid polyketide/non-ribosomal peptide antibiotics and anticancer drugs as well as polyketide based cholesterol lowering agents.

  • structure function and engineering of polyketide synthases
  • hybrid polyketide/non-ribosomal peptide antibiotics and anticancer drugs
  • polyketide based cholesterol lowering agents
  • Memberships

    Organisations

    School of Biochemistry

    Other sites

    Recent publications

    View complete publications list in the University of Bristol publications system

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