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Professor Mark Szczelkun

Professor Mark Szczelkun

Professor Mark Szczelkun
B.Sc.(Liv.), Ph.D.(Soton)

Professor of Biochemistry

Area of research

Prokaryotic immunity systems: mechanisms and applications

Office D45
Biomedical Sciences Building,
University Walk, Clifton BS8 1TD
(See a map)

Tel. +44 (0) 117 331 2158

Research summary

The research focus of the group is the mechanistic analysis of DNA recognition and cleavage by prokaryotic defence systems such as Restriction-Modification and CRISPR. These enzymes protect bacteria from bacteriophages and thus moderate horizontal gene transfer. In addition, they are also important as the basis of many lab tools for manipulating DNA, such as the emergent genome editing technologies.

We use a dual experimental approach to studying DNA-protein interactions – combining single molecule microscopy with ensemble biochemistry, the latter including millisecond time-resolution rapid-mixing fluorescence spectroscopy, molecular biology and protein chemistry. More recently we have established collaborations to extend our studies ...

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Mark has always had a soft spot for DNA. He studied Biochemistry at the University of Liverpool, followed by training in enzymology with Bernard Connolly (Southampton) and Steve Halford FRS (Bristol), elucidating the roles of short- and long-range DNA interactions by restriction enzymes. Supported by the award of a Wellcome Trust Career Development Fellowship, he established his research group in Bristol in 1998. He was amongst the first in the UK to propose applying a combination of single-molecule and ensemble biochemical techniques to the study of genome rearrangements. Following on from the award of a Wellcome Trust Senior Fellowship in ...

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Recent publications

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View complete publications list in the University of Bristol publications system

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