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Publication - Dr Lucia Marucci

    Design of a multicellular feedback control strategy in a synthetic bacterial consortium


    Fiore, G, Matyjaszkiewicz, A, Annunziata, F, Grierson, C, Savery, NJ, Marucci, L & Di Bernardo, M, 2017, ‘Design of a multicellular feedback control strategy in a synthetic bacterial consortium’. in: 2016 IEEE 55th Conference on Decision and Control (CDC 2016): Proceedings of a meeting held 12-14 December 2016, Las Vegas, Nevada, USA. Institute of Electrical and Electronics Engineers (IEEE), pp. 3338-3343


    Living organisms employ endogenous negative feedback loops to maintain homeostasis despite environmental fluctuations. An intriguing challenge in Synthetic Biology is that of designing and implementing synthetic circuits to control host cells’ behavior, thus mimicking what natural evolution has refined and conserved. The high degree of circuit complexity required to accomplish this task, and the intrinsic modularity of classical control schemes, suggest the implementation of synthetic endogenous feedback loops across more than one cell population. The distribution of the sensing, computation and actuation functions required to achieve regulation, to different cell populations within a consortium allows to reduce the genetic engineering in a particular cell and to increase the robustness as well as the possibility of reusing the synthesized circuits. Here we propose and study, in-silico, the design of a synthetic microbial consortium implementing a feedback controller across two cell populations.

    Full details in the University publications repository