Dr Fabio Parmeggiani

Summary

Biography

Degree in Biotechnology, University of Bologna

Ph.D. University of Zurich, with prof. Andreas Pluckthun

Postdoctoral fellow and acting instructor, University of Washington, with prof. David Baker

I work on developing new hybrid computational and experimental methods for protein design. The focus is on modular systems based on designed repeat proteins for spatial control of protein structures and their applications as tools to study and influence cell behaviour.

Memberships

Organisations

School of Chemistry

Other sites

• Biochemistry
• Chemistry

Recent publications

• Geiger-Schuller, K, Sforza, K, Yuhas, M, Parmeggiani, F, Baker, D & Barrick, D, 2018, ‘Extreme stability in de novo-designed repeat arrays is determined by unusually stable short-range interactions’. Proceedings of the National Academy of Sciences of the United States of America, vol 115., pp. 7539-7544
• Yeh, CT, Brunette, TJ, Baker, D, McIntosh-Smith, S & Parmeggiani, F, 2018, ‘Elfin: an algorithm for the computational design of custom three-dimensional structures from modular repeat protein building blocks’. Journal of Structural Biology, vol 201., pp. 100-107
• Fallas, JA, Ueda, G, Sheffler, W, Nguyen, V, McNamara, DE, Sankaran, B, Pereira, JH, Parmeggiani, F, Brunette, TJ, Cascio, D, Yeates, TR, Zwart, P & Baker, D, 2017, ‘Computational design of self-assembling cyclic protein homo-oligomers’. Nature Chemistry, vol 9., pp. 353-360
• Parmeggiani, F & Huang, P-S, 2017, ‘Designing repeat proteins: A modular approach to protein design’. Current Opinion in Structural Biology, vol 45., pp. 116-123
• Reichen, C, Hansen, S, Forzani, C, Honegger, A, Fleishman, SJ, Zhou, T, Parmeggiani, F, Ernst, P, Madhurantakam, C, Ewald, C, Mittl, PRE, Zerbe, O, Baker, D, Caflisch, A & Plückthun, A, 2016, ‘Computationally Designed Armadillo Repeat Proteins for Modular Peptide Recognition’. Journal of Molecular Biology, vol 428., pp. 4467-4489
• Mills, JH, Sheffler, W, Ener, ME, Almhjell, PJ, Oberdorfer, G, Pereira, JH, Parmeggiani, F, Sankaran, B, Zwart, PH & Baker, D, 2016, ‘Computational design of a homotrimeric metalloprotein with a trisbipyridyl core’. Proceedings of the National Academy of Sciences of the United States of America, vol 113., pp. 15012-15017
• Huang, P-S, Feldmeier, K, Parmeggiani, F, Velasco, DAF, Höcker, B & Baker, D, 2016, ‘De novo design of a four-fold symmetric TIM-barrel protein with atomic-level accuracy’. Nature Chemical Biology, vol 12., pp. 29-34
• Doyle, L, Hallinan, J, Bolduc, J, Parmeggiani, F, Baker, D, Stoddard, BL & Bradley, P, 2015, ‘Rational design of α-helical tandem repeat proteins with closed architectures’. Nature, vol 528., pp. 585-8
• Brunette, TJ, Parmeggiani, F, Huang, P-S, Bhabha, G, Ekiert, DC, Tsutakawa, SE, Hura, GL, Tainer, JA & Baker, D, 2015, ‘Exploring the repeat protein universe through computational protein design’. Nature, vol 528., pp. 580-4
• Park, K, Shen, BW, Parmeggiani, F, Huang, P-S, Stoddard, BL & Baker, D, 2015, ‘Control of repeat-protein curvature by computational protein design’. Nature Structural and Molecular Biology, vol 22., pp. 167-74

View complete publications list in the University of Bristol publications system