Research summary

Red blood cell development in health and disease.

In the bone marrow, red blood cells (RBC) are constantly being produced from hematopoietic stem cells (also called progenitor cells), a process called erythropoiesis. The peripheral blood of an individual also contains a host of progenitor cells that can be induced to undergo erythropoiesis. We are developing culture techniques to maximize the production of red blood cells from peripheral blood for the study of erythropoiesis. This involves exploration of the use of synthetic scaffolds environments for blood production and also interactions with stromal cells. The eventual aim being to manufacture enough RBC ...

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Biography

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Links

• Bristol Blood and Transfusion Unit website

Recent publications

• Severn, CE, Eissa, AM, Langford, CR, Parker, A, Walker, M, Dobbe, JG, Streekstra, GJ, Cameron, NR & Toye, AM, 2019, ‘Ex vivo culture of adult CD34+ stem cells using functional highly porous polymer scaffolds to establish biomimicry of the bone marrow niche’. Biomaterials, vol 225.
• Pellegrin, S, Haydn-Smith, K, Hampton-O'Neil, L, Hawley, B, Heesom, K, Fermo, E, Bianchi, P & Toye, A, 2019, ‘Transduction with BBF2H7/CREB3L2 upregulates SEC23A protein in erythroblasts and partially corrects the hypo-glycosylation phenotype associated with CDAII’. British Journal of Haematology, vol 184., pp. 876-881

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View complete publications list in the University of Bristol publications system